The four original nursing colleges in the Western Cape (Carinus, Nico Malan, Sarley Dolly and Otto du Plessis) were amalgamated in 2000 and the Western Cape College of Nursing (WCCN, Single Campus) was established. In 2005, The WCCN (Department of Health) went into an agency agreement with Cape Peninsula University of Technology (CPUT). The aim was to transfer the WCCN into CPUT. However, in November 2017, the intent to terminate the agency agreement between WCCN and CPUT was communicated to all stakeholders.
The Associated Psychiatric Hospital (APH) College was commissioned in May 2006 and absorbed into the WCCN in December 2007. On 01 May 2020, The WCCN Organisational Development Instrument (ODI) was signed off which resulted in the onset of the WCCN multi campus structure (Metro East, Metro West, Boland Overberg & Southern Cape Karoo Campus).
The five nursing schools (Groote Schuur, Tygerberg, Western Cape Rehabilitation Centre, Worcester & George) accredited as Nursing Schools by the SANC, were absorbed by the WCCN in April 2012. Schools were delinked from the responsible Hospitals and absorbed by WCCN (Department of Health). The aforementioned schools functioned as Satellite sites of the mentioned Campuses until a decision was taken to close the nursing schools in 2018.